One-pot synthesis of pharmacologically active secondary and tertiary 1-(3,3-diarylpropyl)amines via rhodium-catalysed hydroaminomethylation of 1,1-diarylethenes

Authors
Rische, T Eilbracht, P
Citation
T. Rische et P. Eilbracht, One-pot synthesis of pharmacologically active secondary and tertiary 1-(3,3-diarylpropyl)amines via rhodium-catalysed hydroaminomethylation of 1,1-diarylethenes, TETRAHEDRON, 55(7), 1999, pp. 1915-1920
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
7
Year of publication
1999
Pages
1915 - 1920
Database
ISI
SICI code
0040-4020(19990212)55:7<1915:OSOPAS>2.0.ZU;2-Z
Abstract
Pharmacologically active secondary and tertiary 1-(3,3-diarylpropyl)amines 1 are prepared in high yields and chemoselectivity by the reaction of 1,1-d iarylethenes 4, primary or secondary amines 5, carbon monoxide and hydrogen in presence of [Rh(cod)Cl](2)/PBu3 as catalyst via a one-pot hydroformylat ion - amine condensation reduction sequence. (C) 1999 Elsevier Science Ltd. All rights reserved.