Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3-amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives.

Authors
Beccalli, EM Clerici, F Gelmi, ML
Citation
Em. Beccalli et al., Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3-amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives., TETRAHEDRON, 55(7), 1999, pp. 2001-2012
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
7
Year of publication
1999
Pages
2001 - 2012
Database
ISI
SICI code
0040-4020(19990212)55:7<2001:IPIAES>2.0.ZU;2-#
Abstract
A simple method to introduce an heteroatom substituent at C-5 of isothiazoi e dioxides is reported. Through Michael addition reaction 5-substituted iso thiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interest for biological studies. (C) 1999 Elsevier Science Ltd. All rights reserved.