A peptide construct containing B-cell and T-cell epitopes from the foot-and-mouth disease viral VP1 protein induces efficient antiviral protection

Authors
Volpina, OM Surovoy, AY Zhmak, MN Kuprianova, MA Koroev, DO Chepurkin, AV Toloknov, AS Ivanov, VT
Citation
Om. Volpina et al., A peptide construct containing B-cell and T-cell epitopes from the foot-and-mouth disease viral VP1 protein induces efficient antiviral protection, VACCINE, 17(6), 1999, pp. 577-584
Citations number
12
Categorie Soggetti
Veterinary Medicine/Animal Health",Immunology
Journal title
VACCINE
ISSN journal
0264410X → ACNP
Volume
17
Issue
6
Year of publication
1999
Pages
577 - 584
Database
ISI
SICI code
0264-410X(19990212)17:6<577:APCCBA>2.0.ZU;2-S
Abstract
A new peptide construct Palm135-158-GGA-170-188(Acm) has been synthesized a nd investigated in a number of in vitro and in vivo test systems. The const ruct contains a virus specific T-helper epitope within the 170-188 sequence of VP1, in addition to the main antigenic 135-158 region of the foot-and-m outh disease viral VP1 protein (strain A(22)) The construct has higher prot ective, antigenic, immunogenic and T-cell proliferative activity then the p reviously described shorter peptide Palm(2)135-159. The 170-188 part of the construct serves as a virus specific T-epitope, responsible for the enhanc ed immunogenic and protective activity of the construct. (C) 1999 Elsevier Science Ltd. All rights reserved.