Asymmetric distribution of phosphatidylethanolamine in C-albicans: Possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily

Citation
S. Dogra et al., Asymmetric distribution of phosphatidylethanolamine in C-albicans: Possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily, YEAST, 15(2), 1999, pp. 111-121
Citations number
37
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
YEAST
ISSN journal
0749503X → ACNP
Volume
15
Issue
2
Year of publication
1999
Pages
111 - 121
Database
ISI
SICI code
0749-503X(19990130)15:2<111:ADOPIC>2.0.ZU;2-2
Abstract
By using two molecular probes, we demonstrate that only 4% of total phospha tidylethanolamine (PtdEtn) in the plasma membrane (PM) of a human pathogeni c yeast, Candida albicans, is present in its external half. Evidence is pre sented to show that the availability of PtdEtn could be related to the expr ession of a multidrug transporter CDR1 of C. albicans, and the process is e nergy-dependent. A homozygous CDR1 disruptant strain of C, albicans shows a lmost 23% reduction in the external labelling of PtdEtn. This report shows that, similar to human MDRs, yeast multidrug transporter could also be invo lved in aminophospholipid translocation. Copyright (C) 1999 John Wiley & So ns, Ltd.