Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase

Crystals of Trypanosoma cruzi dUTPase have been grown. Two different morpho logies are observed, depending on the molecular weight of the PEG used as p recipitating agent in the mother liquor, both having a hexagonal unit cell with similar dimensions Complete X-ray diffraction data have been collected to low resolution for one of the forms. The space group is P6(3)22, with u nit-cell dimensions a = 134.15, c = 147.05 Angstrom. Peaks in the self-rota tion function and the solvent content are consistent with two molecules of dUTPase per asymmetric unit.