Eh. Baldini et al., Patterns of recurrence and outcome for patients with clinical stage II non-small-cell lung cancer, AM J CL ONC, 22(1), 1999, pp. 8-14
Citations number
18
Categorie Soggetti
Oncology
Journal title
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Forty-six patients with pathologic clinical stage II nonsmall-cell lung car
cinoma underwent resection with or without adjuvant radiotherapy from 1989
through 1994. These patients were analyzed to determine patterns of recurre
nce and survival. Surgery consisted of pneumonectomy for 11 patients, bilob
ectomy for two patients, lobectomy for 29 patients, and wedge or segmental
resection for four patients. Adjuvant radiotherapy was delivered to 29 pati
ents, and the median total dose was 54 Gy (range, 44-60 Gy). Median follow-
up time was 23 months for all patients and 25 months for surviving patients
. Twenty-six of 46 patients have had recurrence. The site of first recurren
ce was locoregional for 9 of 46 patients (20%) and distant for 17 of 46 pat
ients (37%). The median time to locoregional recurrence was 18 months for p
atients treated with radiotherapy and 13 months for patients treated withou
t radiotherapy. An isolated locoregional recurrence (with no simultaneous d
istant recurrence) was seen in 2 of 28 evaluable patients (7%) treated with
radiotherapy compared with 3 of 17 patients (18%) not treated with radioth
erapy. For all patients, the 3-year disease-free survival rate was 52%, and
the overall survival rate was 52%. Among patients treated with radiotherap
y, the 3-year disease-free survival and overall survival rates were 56% and
56%, respectively, compared with 46% and 43%, respectively, for patients w
ho did not receive radiotherapy (p values were not significant). The locore
gional recurrence rate was 33% for patients with adenocarcinoma and 15% for
those with squamous cell carcinoma. The distant recurrence rates by histol
ogic characteristic were 56% and 20%, respectively. For patients with clini
cal stage II non-small-cell lung cancer, postoperative radiotherapy appears
to improve locoregional control. However, the preponderance of recurrences
remains distant. Further study is warranted with special emphasis on contr
ol of systemic disease.