L. Grievink et al., Double-blind intervention trial on modulation of ozone effects on pulmonary function by antioxidant supplements, AM J EPIDEM, 149(4), 1999, pp. 306-314
Citations number
36
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
The aim of this study was to investigate whether the acute effects of ozone
on lung function could be modulated by antioxidant vitamin supplementation
in a placebo-controlled study. Lung function was measured in Dutch bicycli
sts (n = 38) before and after each training session on a number of occasion
s (n = 380) during the summer of 1996, The vitamin group (n = 20) received
100 mg of vitamin E and 500 mg of vitamin C daily for 15 weeks. The average
ozone concentration during exercise was 77 mu g/m(3) (range, 14-186 mu g/m
(3)). After exclusion of subjects with insufficient compliance from the ana
lysis, a difference in ozone exposure of 100 mu g/m(3) decreased forced exp
iratory volume in I second (FEV,) 95 mi (95% confidence interval (CI) -265
to -53) in the placebo group and 1 mi (95% CI -94 to 132) in the vitamin gr
oup; for forced vital capacity, the change was -125 mi (95% CI -384 to -36)
in the placebo group and -42 mi (95% CI -130 to 35) in the vitamin group.
The differences in ozone effect on lung function between the groups were st
atistically significant. The results suggest that supplementation with the
antioxidant vitamins C and E confers partial protection against the acute e
ffects of ozone on FEV, and forced vital capacity in cyclists.