Long term consequences of gastrectomy for patients' quality of life: The impact of reconstructive techniques

Objective: During recent years considerable interest has been focused on qu ality of life as an additional therapeutic outcome measure in the surgical treatment of gastric carcinoma. However, the long term consequences of gast rectomy and the impact on quality of life of different reconstructive techn iques are still a matter of controversy. To broaden the criteria for choice of treatment, we conducted a prospective randomized clinical trial to dete rmine the impact of various gastrectomy procedures on quality of life durin g a 5-yr follow-up period. Methods: Consecutive patients (n = 64) eligible for curative gastric cancer surgery were randomized to have either total (n = 31) or subtotal (n = 13) gastrectomy or a jejunal S-shaped pouch (n = 20 ) as a gastric substitute after total gastrectomy. Assessments of quality o f life were made on seven occasions during a 5-yr period: within 1 wk befor e surgery, 3 and 12 months after the surgical intervention, and then once/y r, All patients were interviewed by one of two psychiatrists, who rated the ir symptoms and introduced standardized self-report questionnaires covering both general and specific aspects of life. The raters were blinded for the patients' group affiliations. Results: Survival rates were similar in all treatment groups. Patients who had a total gastrectomy continued to suffer from alimentary symptoms, especially indigestion and diarrhea, during the e ntire follow-up period. However, patients who underwent subtotal gastrectom y had a significantly better outcome already during the first postoperative yr, Patients given a gastric substitute after gastrectomy improved with th e passage of time and had an even better outcome in the long run. Conclusio ns: To optimize the rehabilitation after gastrectomy, patients' quality of life must be taken into consideration. When subtotal gastrectomy is clinica lly feasible, this procedure has advantages in the early postoperative peri od. However, a pouch reconstruction after total gastrectomy should be consi dered in patients having a favorable tumor status suggesting a fair chance of long term survival. (Am J Gastroenterol 1999;94:438-445. (C) 1999 by Am, Cell. of Gastroenterology).