Oxygen saturation, pulse rate, and particulate air pollution - A daily time-series panel study

Citation
Ca. Pope et al., Oxygen saturation, pulse rate, and particulate air pollution - A daily time-series panel study, AM J R CRIT, 159(2), 1999, pp. 365-372
Citations number
35
Categorie Soggetti
Cardiovascular & Respiratory Systems","da verificare
Journal title
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
ISSN journal
1073449X → ACNP
Volume
159
Issue
2
Year of publication
1999
Pages
365 - 372
Database
ISI
SICI code
1073-449X(199902)159:2<365:OSPRAP>2.0.ZU;2-W
Abstract
Although epidemiological studies have linked particulate air pollution with cardiopulmonary mortality, underlying biological mechanisms remain largely unknown. Unexplored pathophysiological pathways include transient declines in blood oxygenation and/or changes in cardiac rhythm following particulat e exposure. In this study, blood oxygen saturation using pulse oximetry (Sp (o2)) and pulse rate were measured daily on a panel of 90 elderly subjects during the winter of 1995-1996 in Utah Valley. Associations of Sp(o2) and p ulse rate with respirable particulate pollution (particles with an aerodyna mic diameter less than or equal to a nominal 10 mu m [PM10]) were evaluated . Sp(o2) was not consistently associated with PM10. Pulse rate and the odds of the pulse rate being elevated by 5 or 10 beats per minute (beats/min) w ere associated with PM10 on the previous 1 to 5 d. A 100 mu g/m(3) increase in previous-day PM10 was associated with an average increase of 0.8 beats/ min and 29 and 95% increased odds of the pulse rate being elevated by 5 or 10 beats/min, respectively. Although there was little evidence of pollution -related hypoxia, alterations in pulse rate could reflect cardiac rhythm ch anges and may be part of the pathophysiology linking particles to cardiopul monary mortality. The observed lag structure is consistent with particulate -induced pulmonary inflammation and cytokine release, but the biological re levance requires further study.