We prospectively investigated the large-scale implementation of a respirato
ry-therapist-driven protocol (TDP) that included 117 respiratory care pract
itioners (RCPs) managing 1,067 patients with respiratory failure over 9,048
patient days of mechanical ventilation. During a 12-mo period, we reintrod
uced a previously validated protocol that included a daily screen (DS) coup
led with spontaneous breathing trials (SBTs) and physician prompt, as a TDP
without daily input from a physician or "weaning team." With graded, stage
d educational interventions at 2-mo intervals, RCPs had a 97% completion ra
te and a 95% correct interpretation rate for the DS. The frequency with whi
ch patients who passed the DS underwent SBTs increased throughout the imple
mentation process (p < 0.001). As the year progressed, RCPs more often cons
idered SBTs once patients had passed a DS (p < 0.001), and physicians order
ed more SBTs (46 versus 65%, p = 0.004). Overall, SBTs were ordered more of
ten on the medicine than on the surgical services (81 versus 63%, p = 0.001
), likely reflecting medical intensivists' prior use of this protocol. impo
rtant barriers to protocol compliance were identified through a questionnai
re (89 respondents, 76%), and included: Physician unfamiliarity with the pr
otocol, RCP inconsistency in seeking an order for an SET from the physician
, specific reasons cited by the physician for not advancing the patient to
a SET, and lack of stationary unit assignments by RCPs performing the proto
col. We conclude that implementation of a validated weaning strategy is fea
sible as a TDP without daily supervision from a weaning physician or team.
RCPs can appropriately perform and interpret DS data more than 95% of the t
ime, but significant barriers to SBTs exist. Through a staged implementatio
n process, using periodic reinforcement of all participants in ventilator m
anagement, improved compliance with this large-scare weaning protocol can b
e achieved.