High performance cocktail functional monomer for making molecule imprinting polymer

In order to make a molecule imprinting polymer (MIP) with highly chiral sel ectivity against N-t-Boc-L-Trp, a new kind of "cocktail" functional monomer : acrylamide+2-vinylpyridine was investigated. The MIP showed impressive ch iral selectivity (alpha=3.23). With the increasing of water content in the mobile phase, ionic and hydrophobic interaction were found to be responsibl e for the chiral recognition process instead of the hydrogen bond. Tailing and peak asymmetry problems were overcome by using linear gradient elution. Physical properties such as thermal stability and pore structure for the M IP were also investigated.