S. Takeichi et al., Association of plasma triglyceride-rich lipoprotein remnants with coronaryatherosclerosis in cases of sudden cardiac death, ATHEROSCLER, 142(2), 1999, pp. 309-315
Citations number
28
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Among the risk factors for coronary atherosclerosis, elevated LDL-C level i
s best known. The action of lipoprotein lipase on triglyceride-rich lipopro
teins produces remnant lipoprotein particles enriched in cholesterol and ap
olipoprotein E (apo E). Apo E serves as the ligand for uptake of remnant li
poproteins via the L.DL-receptor or the remnant receptor. In this study, po
stmortem plasma total cholesterol, triglycerides (TG), VLDL-C, HDL-C, lipop
rotein (a) [Lp(a)] and remnant-like lipoprotein particles (RLP)-cholesterol
, RLP-TG, apolipoproteins B, C III and E were measured, together with LDL-C
to assess their potential contribution to the severity of coronary and aor
tic atherosclerosis of the 197 cases of sudden death (132 cardiac death and
65 non-cardiac death). In all cases, the severity of coronary atherosclero
sis was determined at postmortem pathological examination. RLP-cholesterol
(RLP-C) and LDL-C concentrations were significantly higher in cases with ad
vanced coronary atherosclerosis compared with those without coronary athero
sclerosis; respective median values were 13.5 vs 8.3 mg/dl (P < 0.001) and
140 vs 115 mg/dl (P < 0.05). RLP-C levels were more strongly correlated wit
h the severity score of coronary atherosclerosis than LDL-C. (C) 1999 Elsev
ier Science Ireland Ltd. All rights reserved.