Amino acid release during spreading depression in a flow-compromised cortical area

The glutamate concentrations in dialysate samples obtained from microdialys is probe implanted in the cortex were assayed during artificially induced s preading depression (SD) and SD with hypoperfusion. The glutamate concentra tions did not differ even after SD induction with hypoperfusion (all p > 0. 05 cf. control), whereas anoxic depolarization caused significantly high gl utamate release. Prolonged SD in hypoperfused area did not expose cerebral neurons to high glutamate concentrations. (C) 1999 Elsevier Science B.V. Al l rights reserved.