Altered expression levels of G protein subclass mRNAs in various seizure stages of the kindling model

The expressions of mRNAs encoding G protein alpha subunits were analyzed in the cerebral cortex of amygdaloid kindled rats. a remarkable increase in G c(S alpha) mRNA were observed on the bilateral cerebral cortex at 24 h afte r the last generalized seizure and persisted 3 weeks on the unstimulated si de. G(i2 alpha) mRNA level was also increased on the stimulated side at 24 h and persisted 3 weeks. These result suggest that dysfunction of G(S) and G(i2) might relate to the basic mechanisms of seizure generation and the ma intenance of epileptogenesis. (C) 1999 Elsevier Science B.V. All rights res erved.