Intra-molecular dynamics in biologically active 3H-pyrido[2,3-d]pyrimidin-4-on derivatives investigated by H-1 NMR

Intra-molecular dynamics of homologue pyrimidin-4-on derivatives exhibiting different depressive, analgetic and convulsive generator activity has been studied and experimental thermodynamic parameters have been correlated wit h semiempirical AM1 calculation results. Simulated spatial structures of ro tamers in selected transition states have been proposed.