Ib. Cheglakov et al., INFLUENCE OF MIBEFRADIL ON CA2+ INFLUX INDUCED BY VASOACTIVE HORMONESOR DEPLETION OF INTRACELLULAR CALCIUM STORES, Arzneimittel-Forschung, 47(3), 1997, pp. 244-247
The influence of the new calcium antagonist mibefradil (GAS 116666-63-
8, Ro 405967) on calcium influx into rabbit smooth muscle cells (VSMC)
was studied. Angiotensin II-stimulated divalent cations entry was blo
cked by mibefradil at micromolar concentrations (1-10 mu mol/l). In th
e same range of concentrations, the antagonist depressed capacitative
calcium influx evoked by thapsigargin- and 2,5-di-tert-butylhydroquino
ne (BHQ)-dependent depletion of internal depots. The ability to block
the receptor-mediated pathway of calcium current into VSMC may explain
in part the difference between the mode of pharmacological action of
mibefradil as compared to other calcium antagonists.