Benzene-bridged hexaalkynylphenylalanines and first-generation dendrimers thereof

The palladium-mediated coupling of p-ethynylphenylalanine (p-epa) with hexa bromobenzene yielded a benzene-bridged hexaalkynyl alpha-amino acid in high yield. The use of the hexapodal amino acid and of the corresponding tripod al amino acid as backbones for the synthesis of first-generation dendrimers based on poly(trishydroxymethyl) and poly(ornithine) compounds, developed by Newkome et al., Denkewalter et al., and Tam et al., is described.