CHARACTERIZATION OF CLOFAZIMINE METABOLITES IN HUMANS BY HPLC-ELECTROSPRAY MASS-SPECTROMETRY

Authors
KRISHNA DR MAMIDI RNVS HOFMANN U PRABHAKAR CM
Citation
Dr. Krishna et al., CHARACTERIZATION OF CLOFAZIMINE METABOLITES IN HUMANS BY HPLC-ELECTROSPRAY MASS-SPECTROMETRY, Arzneimittel-Forschung, 47(3), 1997, pp. 303-306
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
47
Issue
3
Year of publication
1997
Pages
303 - 306
Database
ISI
SICI code
0004-4172(1997)47:3<303:COCMIH>2.0.ZU;2-X
Abstract
Clofazimine (GAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass sp ectrometry. The resulting analytical data, extraction, isolation and c haracterization methods are presented. Their applicability is describe d for human urine analysis.