Myotonic dystrophy associated with QT prolongation and torsade de pointes

Citation
Y. Umeda et al., Myotonic dystrophy associated with QT prolongation and torsade de pointes, CLIN CARD, 22(2), 1999, pp. 136-138
Citations number
10
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
CLINICAL CARDIOLOGY
ISSN journal
01609289 → ACNP
Volume
22
Issue
2
Year of publication
1999
Pages
136 - 138
Database
ISI
SICI code
0160-9289(199902)22:2<136:MDAWQP>2.0.ZU;2-0
Abstract
A rare case of myotonic dystrophy (MD) with congestive heart failure, assoc iated with QT prolongation and torsade de pointes (TdP) is reported. A 53-y ear-old woman was admitted to the hospital because of congestive heart fail ure. Electrocardiograph (ECG) showed first-degree atrioventricular block an d QT prolongation. During hospitalization, TdP appeared but returned to sin us rhythm spontaneously. As the patient had quadriplegia, a myopathic face, cataracts, diabetes mellitus, and an increased number of cytosine-thymine- guanine (CTG) repeats (760 repeats), she was diagnosed as having MD. Electr ocardiographic analysis of her family also revealed abnormal QT(U) prolonga tion in her daughter and brother who both had MD, while ECG findings of oth er family members without MD were normal. Thus, the presence of QT(U) prolo ngation was associated with MD in this family.