Structure-based and combinatorial search for new RNA-binding drugs

Authors
Afshar, M Prescott, CD Varani, G
Citation
M. Afshar et al., Structure-based and combinatorial search for new RNA-binding drugs, CURR OPIN B, 10(1), 1999, pp. 59-63
Citations number
47
Categorie Soggetti
Microbiology
Journal title
CURRENT OPINION IN BIOTECHNOLOGY
ISSN journal
09581669 → ACNP
Volume
10
Issue
1
Year of publication
1999
Pages
59 - 63
Database
ISI
SICI code
0958-1669(199902)10:1<59:SACSFN>2.0.ZU;2-X
Abstract
The discovery by structure-based and combinatorial methods of new RNA-bindi ng drugs presents great opportunities for pharmacological development again st drug-resistant bacterial and viral pathogens. A handful of recent RNA st ructures and more numerous studies of the interaction of combinatorial libr aries and oligomeric RNA-binding compounds are providing the foundation for effective RNA-targeted drug discovery programs.