The complete pneumococcal genome sequence was released in November, 1997 Th
is advance has been combined with new understanding of physiology and patho
genesis including characterization of a family of surface proteins adducted
to choline, regulation of virulence, and the regulon for natural DNA trans
formation These developments in our understanding of molecular and cellular
biology of pneumococcal infection will allow the development of new vaccin
es and antibiotics against this community acquired pathogen.