Interaction of Salmonella with host cells through the centisome 63 type III secretion system

Salmonella enterica engages host cells in a complex two-way biochemical int eraction that results in a variety of responses from both the bacteria and the host cell. Central to this interaction is the function of a type III pr otein secretion system that delivers effector proteins into the host cell. During the past year we have seen major advances in our knowledge of both t he bacterial determinants and the host-signal transduction pathways involve d in these interactions. A coherent picture of the mechanisms by which Salm onella engages the host cell is now beginning to emerge.