Mechanism of Shigella entry into epithelial cells

Authors
Van Nhieu, GT Sansonetti, PJ
Citation
Gt. Van Nhieu et Pj. Sansonetti, Mechanism of Shigella entry into epithelial cells, CURR OPIN M, 2(1), 1999, pp. 51-55
Citations number
23
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274 → ACNP
Volume
2
Issue
1
Year of publication
1999
Pages
51 - 55
Database
ISI
SICI code
1369-5274(199902)2:1<51:MOSEIE>2.0.ZU;2-R
Abstract
Shigella, the causative agent of bacillary dysentery, invades epithelial ce lls by reorganizing the cell cytoskeleton during bacterial entry. This entr y process requires the Shigella Ipa proteins that are secreted by a type II I secretion apparatus and that act in concert to fine tune cell responses. Actin polymerization at the site oi entry is dependent on the IpaB and IpaC proteins, whereas IpaA further modulates cytoskeletal rearrangements by bi nding to vinculin.