We have localized a human homolog, REV3L, of the Saccharomyces cerevisiae R
EV3 gene on chromosome region 6q21. The full-length cDNA consists of 10,919
nucleotides, with a putative open reading frame of 9,159 bp for a predicte
d protein of 3,053 amino acids. The gene contains 33 exons in about 200 kb
of genomic DNA. In contrast to the previously reported sequence, an additio
nal exon and an alternative splicing site are demonstrated.