The gene encoding the transcriptional repressor BERF-1 maps to a region ofconserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8

We have recently identified and characterized a Kruppel-like zinc finger pr otein (BERF-1), that functions as a repressor of beta enolase gene transcri ption. By interspecific backcross analysis the gene encoding BERF-1 was loc alized 4.7 cM proximal to the Mtv6 locus on mouse chromosome 16, and an iso lated pseudogene was localized to mouse chromosome 8, about 5.3 cM distal t o the D8Mit4 marker. Nucleotide sequence identity and chomosome location in dicate that the gene encoding BERF-1 is the mouse homologue (Zfp148) of ZNF 148 localized to human chromosome 3q21, a common translocation site in acut e myeloid leukemia patients.