Selective expression of purinoceptor cP2Y(1) suggests a role for nucleotide signalling in development of the chick embryo

Responses to extracellular nucleotides (e.g,, ATP, ADP, etc.) have been dem onstrated in a number of embryonic cell types suggesting they may be import ant signalling molecules during embryonic development. Here the authors des cribe for the first time the expression of a G-protein-coupled receptor for extracellular ATP, chick P2Y(1) (cP2Y(1)), during embryonic development of the chick. During the first 10 days of embryonic development, cP2Y(1) is e xpressed in a developmentally regulated manner in the limb buds, mesonephro s, brain, somites, and facial primordia, suggesting that this receptor may have a role in the development of each of these systems, Dev Dyn 1999;214:1 52-158. (C) 1999 Wiley-Liss, Inc.