Two novel biallelic polymorphisms in the IL-2 gene

Authors
John, S Turner, D Donn, R Sinnott, P Worthington, J Ollier, WER Hutchinson, IV Hajeer, AH
Citation
S. John et al., Two novel biallelic polymorphisms in the IL-2 gene, EUR J IMM, 25(6), 1998, pp. 419-420
Citations number
5
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOGENETICS
ISSN journal
09607420 → ACNP
Volume
25
Issue
6
Year of publication
1998
Pages
419 - 420
Database
ISI
SICI code
0960-7420(199812)25:6<419:TNBPIT>2.0.ZU;2-I
Abstract
We have detected two novel single nucleotide polymorphisms in the IL-2 gene , at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The -330 polymorphism has two common alleles, making it an ideal marker for genetic association studies.