Voltammetry of trazodone by platinum electrode and its determination in tablets using DP technique in the rotating conditions

The voltammetric behaviors of trazodone using a platinum electrode in stati onary or rotating conditions and its determination in tablets by DP rotatin g electrodes are described in this study. The experiments were conducted in the supporting electrolyte consisting of 0.2 M KCl and 0.2 M acetate or ph osphate buffer. No adsorption was observed at +300 mV. The factor affecting the voltammetric current was diffusional in the range of 200-2000 rpm for rotating, and 2-10 mV potential rate for stationary conditions; and the cal ibration dependence was linear between 1x10(-5)-5x10(-5) M trazodone soluti ons. The detection limit was found to be 2.5x10(-6) M (s(b)=5.03, n=5) for stationary and 1.7x10(-6) M (s(b)=2.12, n=5) for rotating electode assuming a signal to noise ratio of 3. According to the statistical evaluations, ac ceptable results were obtained at the 95% probability level. Therefore, the proposed method is practicable, sensitive and accurate for the analysis of trazodone preparations in quality control laboratories. (C) 1999 Elsevier Science B.V. All rights reserved.