D. Dogrukol-ak et al., Voltammetry of trazodone by platinum electrode and its determination in tablets using DP technique in the rotating conditions, EUR J PH SC, 7(3), 1999, pp. 215-220
The voltammetric behaviors of trazodone using a platinum electrode in stati
onary or rotating conditions and its determination in tablets by DP rotatin
g electrodes are described in this study. The experiments were conducted in
the supporting electrolyte consisting of 0.2 M KCl and 0.2 M acetate or ph
osphate buffer. No adsorption was observed at +300 mV. The factor affecting
the voltammetric current was diffusional in the range of 200-2000 rpm for
rotating, and 2-10 mV potential rate for stationary conditions; and the cal
ibration dependence was linear between 1x10(-5)-5x10(-5) M trazodone soluti
ons. The detection limit was found to be 2.5x10(-6) M (s(b)=5.03, n=5) for
stationary and 1.7x10(-6) M (s(b)=2.12, n=5) for rotating electode assuming
a signal to noise ratio of 3. According to the statistical evaluations, ac
ceptable results were obtained at the 95% probability level. Therefore, the
proposed method is practicable, sensitive and accurate for the analysis of
trazodone preparations in quality control laboratories. (C) 1999 Elsevier
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