[D-Ala(2), D-Leu(5)]enkephalin blocks the methamphetamine-induced c-fos mRNA increase in mouse striatum

Authors
Hayashi, T Tsao, LI Cadet, JL Su, TP
Citation
T. Hayashi et al., [D-Ala(2), D-Leu(5)]enkephalin blocks the methamphetamine-induced c-fos mRNA increase in mouse striatum, EUR J PHARM, 366(2-3), 1999, pp. R7-R8
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
366
Issue
2-3
Year of publication
1999
Pages
R7 - R8
Database
ISI
SICI code
0014-2999(19990205)366:2-3<R7:[DBTMC>2.0.ZU;2-Q
Abstract
The administration of methamphetamine caused an increase of c-fos mRNA in t he striatum of the mouse. A systemic injection of the delta-opioid receptor agonist, [D-Ala(2), D-Leu(5)]enkephalin (DADLE), attenuated the c-Sos mRNA increase induced by methamphetamine. These results suggest that endogenous S-opioid peptides might counteract certain genomic influences exerted by p sychostimulants such as methamphetamine. (C) 1999 Elsevier Science B.V. All rights reserved.