Lung function in school-aged asthmatic children with inhaled cromoglycate,nedocromil and corticosteroid therapy

Two-thirds of the children with asthma in our al ea use cromones and only o ne-third steroids as the maintenance therapy. This study aimed to evaluate our treatment policy based on the international consensus. Peak expiratory flow (PEF), dynamic spirometry and bronchodilation test res ults were therefore collected in 195 school-aged patients who visited our o utpatient clinic in 1995. Sixty-four children (33%) used cromoglycate, 86 ( 44%) nedocromil and 45 (23%) inhaled steroids. Twenty-five (12%) needed com bination therapy, mainly with salmeterol. Lung function results were good, and there were no significant differences between the therapeutic groups irrespective of whether pre- or postbronchod ilator values were considered. PEF was decreased in eight (4%), forced expi ratory volume in one second (FEV1) in four (2%) and maximum mid-expiratory flow (MMEF) in 33 (17%) patients. At least one result was decreased in 39 ( 20%) cases, in most casts (77%) MMEF alone. Significant rises after salbuta mol inhalations were observed in 17 (9%) in PEF, in two (1%) in FEV1 and 20 (10%) in MMEF values. Thus, the bronchodilation test was positive in 33 (1 7%) cases, and in 22 (11%) cases it was the only sign of bronchial obstruct ion. Over 70% of the children with asthma can be treated with cromones by a step wise treatment modality. Inhaled steroids call be restricted to those not c ontrollable by cromones. Lung function tests, including postbronchodilator values, should be part of the follow-up of continuous maintenance medicatio n for asthma.