In the present study the costs of schizophrenia in Germany were studied usi
ng the "bottom up" prevalence-based method. In a random sample of 180 schiz
ophrenic patients stratified according to the most important care instituti
ons, direct and indirect costs were retrospectively documented for a 12-mon
th period. Depending on the place of recruitment and the extent of care pro
vided, total yearly costs result between about DM 33,000 for a patient trea
ted predominantly on an outpatient basis and about DM 126,000 for a patient
requiring hospital care and about DM 135,000 for a patient in job rehabili
tation. The direct yearly treatment costs were, as expected, lowest for pat
ients recruited in the private practice of a psychiatrist and predominantly
treated on an outpatient basis (DM 5,788), and were the highest in the psy
chiatric hospital (DM 64,661) and in job rehabilition (DM 79,996). In the p
atients recruited in the outpatient domain, doctors' fees and medication to
gether were responsible for only 4.5% of the total costs, whereas the indir
ect costs (e.g. through work incapacity) were responsible for 87% of the to
tal yearly costs. For methodological reasons the total costs caused by schi
zophrenic psychoses in Germany per year can at present be estimated only ro
ughly. A conservative estimate is between 8.5 and 18 billion DM per year. T
he study shows that schizophrenia is a very expensive illness, the direct a
nd indirect costs of which are on the whole comparable to those of the comm
on somatic illnesses. Therefore, also for economical reasons, sufficient fi
nancial means should be invested in the research and treatment of this seve
re illness.