Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma

We analyzed 23 samples of primary pediatric ependymoma for significant gain s or losses of genomic DNA, using comparative genomic hybridization (CGH) a nd a rigorous statistical approach. Nine of the tumors in this series (39%) appeared normal by CGH. The remainder had a limited number of regions of g enomic imbalance, most often involving losses of chromosome arms 6q and 22q and the X chromosome, or gains of either 1q or 9. Recurrent and exclusive losses of 6q or 22q suggest that these regions harbor tumor suppressor gene s that may contribute independently to the pathogenesis of childhood ependy moma. Genes Chromosomes Cancer 24:230-237, 1999. (C) 1999 Wiley-Liss, Inc.