HMGI is not rearranged by 13q12 aberrations in lipomas

Several cytogenetic subgroups with characteristic lesions involving chromos omal regions 12q14-15, 6p21.3, or 13q12 can be distinguished in lipomas. Re arrangements of the HMG1C gene have been described in cases with 12q14-15 a bnormalities, whereas HMG1Y has been shown to be the target gene of 6p21.3 aberrations. Recently, HMG1, another member of the HMG family, was mapped t o 13q12. The aim of this study was to investigate the possible role of HMG1 aberrations in lipomas with 13q12 abnormalities. Two PAC clones containing HMG1 were isolated. By molecular cytogenetic investigations using these PA C clones and by Southern blot analysis of eight lipomas with 13q12 abnormal ities, we were able to show that these chromosomal rearrangements did not r esult in intragenic rearrangements of HMG1 or breakpoints close to it. Gene s Chromosomes Cancer 24:290-292, 1999. (C) 1999 Wiley-Liss, Inc.