"KARIBIN," an information resource for obtaining genomic information in a cytogenetic band

KARIBIN [http://sgiweb.ncbi.nlm.nih.gov:80/Zjing/yac.html] is a karyotypic region-based integrated information resource that provides a comprehensive view of the integrated mapping and sequencing data for the human genome. A cytogenetic band is linked to a genetic or physical location using fluoresc ence in situ hybridization (FISH) mapping data. The genetic, physical mappi ng data and the sequencing data are integrated using STS markers positioned on multiple maps. For each cytogenetic band, the user can obtain the most up-to-date information that includes genetic and physical maps, human trans cript gene map, YAC and PAC/BAC clone coverage, disease gene phenotype, and high throughput genomic sequences from the major human genome sequencing c enters. This information provides a framework for future experiments and ma y accelerate the process of disease gene hunting. It is envisioned that oth er cytogenetic-based information such as chromosome aberrations can be link ed to this framework.