MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response

Class II multimer formation is an important event in immune recognition. No t only is multimerization a prerequisite for T cell activation, but it is a signal to APC. In the present article, we propose that multimerization can result in the specific removal of ligand complexes from the cell surface o f the APC, an event which may influence the overall pattern of T cell react ivity.