Prognostic factors of nasopharynx tumors investigated by MR imaging and the value of MR imaging in the newly published TNM staging

Purpose: To examine the usefulness of MR imaging for predicting local contr ol of nasopharyngeal carcinoma (NPC) and the value of MR imaging in the new ly published fifth edition of the TNM classification. Methods and Materials: We studied 29 patients with NPC with MR imaging and CT before and after treatment. Staging was done according to the fourth and newly published fifth editions of the International Union Against Cancer ( UICC) staging system. The radiotherapy protocol was designed to deliver 66 to 68 Gy to the primary tumor and clinically involved nodes. Results: MR proved better than CT at identifying obliteration of the pharyn gobasilar fascia, invasion of the sinus of Morgagni, through which the cart ilaginous portion of the eustachian tube and the levator veli palatini musc le pass, invasion of the skull base, and metastases to lymph nodes in the c arotid and retropharyngeal spaces. All seven patients without invasion of t he pharyngobasilar fascia had local control. The local control rates of pat ients with invasion of the skull base were not good (60 to 73%). There was no apparent relationship between tumor volume determined by T1-weighted MR images and local control when the tumor volume was more than 20 cc. The new ly published N staging system appears to successfully identify the high-ris k group for distant metastasis as N3. In our series, four of five patients with N3 disease developed distant metastases. Conclusion: Deep infiltration of the tumor is a more important prognostic f actor in NPC than tumor volume. Since the newly published T staging system requires a search for tumor invasion into soft tissue such as parapharyngea l space and bony structures, MR imaging may be indispensable for the newly published NPC staging system. (C) 1999 Elsevier Science Inc.