Autoimmune cholangitis in a patient with celiac disease: a case report andreview of the literature

Autoimmune cholangitis is a rare chronic cholestatic liver disease. We desc ribe the case of a 65-year-old woman with celiac disease who presented to u s with fever, jaundice and weight loss. Serum biochemical study showed mark ed increase in alkaline phosphatase and gamma GT levels. Antinuclear antibo dies were positive, while antimitochondrial and anti-smooth-muscle antibodi es were negative. Liver biopsy was compatible with primary autoimmune chola ngitis. The patient was successfully treated with azathioprine and methylpr ednisolone. We describe here the uncommon association of autoimmune cholang itis with celiac disease and review the prevalence of liver diseases in pat ients with celiac disease.