The renoprotective effect of antihypertensive drugs

Some antihypertensive drugs may have a renoprotective effect, that is parti ally independent of their ability to reduce blood pressure. ACE-inhibitors are safe and effective agents that are capable of reducing proteinuria and preventing CRF progression The results of the AIPRI extension study suggest that they may also have a long-term renoprotective effect. ACE gene polymo rphism may partially influence the response to these agents. Angiotensin II receptor 1 antagonists (AT1RA) are effective in reducing proteinuria, but their clinical impact is still a matter of study. It has been shown that no n dihydropyridine and some dihydropyridine calcium channel blockers (CCBs) reduce proteinuria and are also renoprotective, but there is a lack of larg e-scale prospective randomised trials. Given that the use of various drugs is usually needed to achieve good blood pressure control in patients with C RF, the possibility that a combination of ACE-inhibitors with CCBs or AT1RA s may have an additive renoprotective effect is intriguing.