B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality

We studied the susceptibility of B cell-deficient mice to encephalomyelitis following intraperitoneal inoculation of HSV-1. B cell-deficient mice deve loped striking CNS signs including tail atony, clumsy gait and limb paralys is after HSV-1 infection. In addition, B cell-deficient mice had decreased survival (LD50 = 2.2 x 10(7) PFU) compared to control C57BL/6 mice (LD50 = 2.3 x 10(8) PFU). B cell-deficient mice had encephalomyelitis and detectabl e virus in the brain 7 days post-infection while C57BL/6 mice did not. Pass ive transfer of hyperimmune sera protected B cell-deficient mice from death , suggesting a role for antibody in susceptibility to HSV-1 encephalomyelit is. (C) 1999 Elsevier Science B.V. All rights reserved.