Enantiomeric separation of optically active pyridazinone derivatives by chiral HPLC

Authors
Bidlo-Igloy, M Matyus, P
Citation
M. Bidlo-igloy et P. Matyus, Enantiomeric separation of optically active pyridazinone derivatives by chiral HPLC, J PHARM B, 19(3-4), 1999, pp. 487-490
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
19
Issue
3-4
Year of publication
1999
Pages
487 - 490
Database
ISI
SICI code
0731-7085(199903)19:3-4<487:ESOOAP>2.0.ZU;2-T
Abstract
Several 4,5-disubstituted 3(2H)-pyridazinone derivatives containing 2-hydro xymethylpyrrolidino moiety as a chiral building block were synthetized. Sep aration of enantiomers was carried out by chiral HPLC on Chiralcel OJ and O F columns. Mobile phases consisted of hexane, ethanol and 2-propanol. Chira lcel OJ column was capable of separating most of the enantiomeric pairs. Fo r one type of compound, Chiralcel OF column was used for separation. (C) 19 99 Elsevier Science B.V. All rights reserved.