Human immunoglobulin G (IgG) serves as an important chemotherapeutic agent
for a number of immunological ailments and as a carrier in the targeted del
ivery of other therapeutic agents. This paper deals with the characterizati
on of IgG-dispersed monolithic matrixes of different geometries, prepared u
sing a nonbiodegradable polymer carrier EVAc. The morphological changes ass
ociated with the matrix during drug release was studied using scanning elec
tron microscopy, polarizing microscopy, atomic force microscopy, and X-ray
photoelectron microscopy, and the results were compared. The study answered
the burst effect problem significantly and illustrated the potential of th
ese techniques in understanding the morphological structure of matrixes and
mode of release kinetics.