Protein kinase C in normal and pathologic myocardial states

Recent evidence has implicated protein kinase C (PKC) as an important media tor underlying multiple aspects of myocardial function. We and others have recently reported that PKC is involved in Ca2+-induced inotropy, in mediati ng myocardial preconditioning by diverse stimuli both in animals and humans , and in the signaling processes which lead to the production of proinflamm atory mediators (cytokines). The purposes of this manuscript are ten explor e the role of PKC in normal myocardial contraction, the role of PKC in medi ating protection, the role of PKC: in inflammation, and the importance of i nflammation regarding myocardial injury. (C) 1999 Academic Press.