Successfully treated central nervous system Burkitt's lymphoma with minimal extraneural disease in a child

Burkitt's lymphoma, the most common childhood non-Hodgkin's lymphoma, usual ly presents with abdominal tumors. Central nervous system (CNS) involvement in Burkitt's lymphoma is mostly secondary to advanced systemic disease. Th is 10-year-old immunocompetent boy presented with increased intracranial pr essure and seizures and was found to have multifocal intracerebral lesions on brain imaging studies. Cerebrospinal fluid studies confirmed the presenc e of Burkitt's lymphoma cells. Abdominal computed tomography showed bilater al nephromegaly with left intrarenal lesions that disappeared after three d oses of intravenous dexamethasone. The patient was treated for 6.5 months a ccording to the LMB 89 group C protocol of the French Pediatric Oncology So ciety. The response was brisk and complete. The patient has been disease fr ee for more than 4 years, and is believed to be cured.