Prognostic value of Doppler-derived mitral deceleration time in postinfarction patients with left ventricular ejection fractions of 35% or more

Short Doppler-derived mitral deceleration time of early filling has been pr oved to be an independent predictor of poor prognosis in patients with left ventricular dysfunction. However, the prognostic value of Doppler-derived mitral deceleration time in postinfarction patients without overt left vent ricular dysfunction is poorly understood. A total of 27 survivors of acute myocardial infarction with left ventricular ejection fractions of 35% or mo re, as determined by radionuclide ventriculography, were prospectively stud ied. Doppler study was performed 5 to 7 days after the index infarction. Th e patients were divided into two groups. Group A included 10 patients whose mitral deceleration time was 125 msec or less and group B consisted of 17 patients whose mitral deceleration time was 125 msec or more. The two group s were similar in terms of age and gender distribution and there were no st atistically significant differences in coronary risk factors, peak creatine kinase concentration, location of infarction, Killip classification. throm bolytic therapy, left ventricular ejection fraction, or medications, After a mean follow-up period of 30 months, the rate of congestive heals failure (New York Heart Association, NYHA, class II or above) was significantly hig her in group A (5/10) than in group B (1/ 17) (p < 0.01). These results sug gest that a short mitral deceleration time could be a useful early predicto r of the potential development of future congestive heart failure in postin farction patients with left ventricular ejection fractions of 35% or more.