Unrelated donor bone marrow transplantation in adults: Some current controversies

The results of unrelated donor bone marrow transplantation are continually improving. These improved results are due to a better understanding of the complications of the procedure and the devising of strategies to avoid them . Nonetheless, many problems remain. This review will address some of the m ajor controversies of the field including the indications for UD-BMT, infec tion, GVHD prophylaxis and treatment and whether UD-BMT should only be perf ormed in specialist centres. Conclusions will be supported by evidence from the limited published literature and the authors' experience in 3 major tr ansplant centres.