Chronic eosinophilic leukemia: Successful treatment with an unrelated bonemarrow transplantation

The optimal treatment of eosinophilic leukemia is still uncertain. We repor t the successful treatment of a 21-year-old patient with eosinophilic leuke mia, without cytogenetic abnormalities, by bone marrow transplantation from an unrelated donor. The conditioning regimen for the transplantation consi sted of fractionated total body irradiation and cyclophosphamide. Acute GVH D, grade I, post-transplantation was successfully treated. No other severe complications occured. The patient is alive in complete remission 21 months after unrelated bone marrow transplantation.