A comparative study of DNA interaction with different counterions in soluti
on has been conducted by the following methods: flow birefringence (FB), lo
w-gradient viscometry, circular dichroism (CD), and UV-spectroscopy. The in
fluence of counterions on the persistence length and polyelectrolyte swelli
ng of DNA has been investigated. The process of DNA packing during the inte
raction with trivalent ions in solution has been studied, as well as the in
fluence of Mn2+ on the binding of trivalent ions with DNA.