Combined hydrophobic and electrostatic interaction-based recognition in molecularly imprinted polymers

Citation
Sa. Piletsky et al., Combined hydrophobic and electrostatic interaction-based recognition in molecularly imprinted polymers, MACROMOLEC, 32(3), 1999, pp. 633-636
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MACROMOLECULES
ISSN journal
00249297 → ACNP
Volume
32
Issue
3
Year of publication
1999
Pages
633 - 636
Database
ISI
SICI code
0024-9297(19990209)32:3<633:CHAEIR>2.0.ZU;2-F
Abstract
Molecularly imprinted polymers selective for D- and L-phenylalanine have be en prepared in water solution using 2-acryloylamido-2,2'-dimethylpropane su lfonic acid and bisacryloyl beta-cyclodextrin as functional monomers, and N ,N'-diacryloylpiperazine as cross-linker. Polymer-ligand recognition was ev aluated using a combination of HPLC, displacement chromatography and fluore scence spectroscopic studies. HPLC studies revealed that the imprinted poly mers possess optimal ligand selectivity in 30% water solution in acetonitri le. The results demonstrate that a balance of hydrophobic and electrostatic interactions is required for ligand recognition by these polymers. The imp rinting effect is sufficiently strong to reverse the inherent chiral select ivity of the cyclodextrin molecule.