Expression of Drosophila trithorax-group homologues in chick embryos

Mil, Brg1 and Bmt are vertebrate homologues of Drosophila trithorax group ( trxG) genes. We isolated chicken Mll cDNA clones, and examined patterns of Mil, Brg1 and Brm expression in chick embryos. All three genes were express ed from embryonic stage 2 onwards. Mll transcripts were just detectable in all tissues by in situ hybridization, with highest levels in dorsal neural tube and notochord. Brg1 transcripts were readily detectable in all tissues , with highest levels in dorsal neural tube, dorsal trunk epithelium and li mb bud epithelium and mesenchyme. Brm transcripts were more restricted, bei ng found in dermomyotome, notochord, dorsal limb bud epithelium, eye and th e roof and floor plates of the neural tube. (C) 1999 Elsevier Science Irela nd Ltd. All rights reserved.