Methodologists have recently shown how the methods of individual growth mod
eling and covariance structure analysis can be integrated, bringing the fle
xibility of the latter to bear on the investigation of inter-individual dif
ferences in change. The individual growth-modeling framework uses a pair of
hierarchical statistical models to represent: (a) individual status as a f
unction of time, and (b) inter-individual differences in true change. Under
the covariance structure approach, these level-1 and level-2 models can be
reformatted as the "measurement" and "structural" components of the genera
l LISREL model with mean structures. Consequently, a covariance structure a
nalysis of longitudinal panel data can provide maximum-likelihood estimates
for all level-2 parameters. In this article, using longitudinal data drawn
from a school-based alcohol prevention trial, we demonstrate how the new a
pproach can be used to investigate the inter-relationships among simultaneo
us individual changes in two domains - positive and negative alcohol expect
ancies - over the course of early to mid-adolescence, for both boys and gir
ls. We represent individual change over time in positive expectancies with
a piecewise growth model, and in negative expectancies with a straight-line
growth model. Then, we use multi-sample covariance structure analysis to a
sk whether individual changes in positive and negative expectancies are rel
ated to each other and whether the pattern of inter-relationships differs b
y gender. Our approach can easily be generalized to more than two domains a
nd has a variety of other advantages that we document in the discussion.